RETINOID REGISTER · KNOW YOUR ACTIVERESEARCHED OCTOBER 2026
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Advertising disclosure: CoreAge Rx is our featured commercial partner and appears first. Placement is promotional; it is not a clinical superiority ranking. How we are funded
The reading list

Why retinoid percentages are not a universal strength ladder

A decimal point only becomes useful when the ingredient and formulation are known.

Keep like ingredients together

Musely publishes several tretinoin concentrations, while Medik8 publishes retinal strengths and Differin specifies adapalene 0.1%. These numbers describe different compounds and products.[source][source][source]

Sorting them numerically would create a false ranking. The same percentage across different molecules does not establish equal potency, delivered exposure or visible results.

Even one ingredient does not make every product identical

A cream’s vehicle, additional actives and instructions can differ. A higher concentration is one formulation fact, not a conclusion that the product is preferable for a particular person.

The prescribing question is what strength fits the concern and tolerance history, and when the response should be reviewed. A commercial range with several levels is not a requirement to progress through all of them.

Leave missing specifications visible

CoreAge Rx’s Smooth Move page names tretinoin without establishing a verified concentration for this publication. HydroTret has customized options, including a tretinoin-free route.[source][source]

Those facts should lead to a request for the actual prescription, not a guess based on a familiar bottle name. A comparison becomes more trustworthy when it acknowledges what cannot yet be compared. Price and a maximum marketed strength do not resolve the missing specification.

THE RESEARCH

Sources & further reading

Provider pages establish what a brand markets. Clinical and regulatory sources establish the limits of the evidence. Accessed October 8, 2026.

  1. Musely: Anti-Aging Cream formulationsOfficial source; checked October 8, 2026
  2. Medik8: Crystal RetinalOfficial source; checked October 8, 2026
  3. DailyMed: Differin 0.1% Drug FactsOfficial source; checked October 8, 2026
  4. CoreAge Rx: Smooth MoveOfficial source; checked October 8, 2026
  5. Curology: HydroTret RxOfficial source; checked October 8, 2026

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